New publication on â€œsymmetry breaking in ensembles of ES cellsâ€
Progress on our attempts to understand the connection between genes, signals, cells and embryos have just been published in Development. In a first paper we describe a new experimental system in which we coax mouse Embryonic Stem cells to make structures with an anterior posterior axis and a germ layer organization that resembles that of an embryo (https://dev.biologists.org/content/141/22/4231.full). In a second paper we use this experimental system to gain some insights into the emergence of the spinal cord (https://dev.biologists.org/content/141/22/4243.full).
You can see a movie and some thoughts on the experiments here: https://www.cam.ac.uk/research/news/shaping-up-researchers-reconstruct-early-stages-of-embryo-development
More on this will follow soon.